Main profile

Subhasis Chattopadhyay

School: 

Biological Sciences

Designation: 

Associate Professor

Education: 

• M.Sc in Zoology, University of Calcutta, Kolkata, India, 1998

• Ph.D from Department of Immunology, Indian Institute of Chemical Biology, Jadavpur University,   
  Kolkata, India, 2003
•  Post Doctoral Fellow, Department of Medicine, University of Connecticut Health Center, USA : 2003-2006 
•  Post Doctoral Fellow, Department of Immunology, University of Connecticut Health Center, USA : 2006-2008

Specialisation: 

Cellular Immunology: Infection Immunity, Cancer Immunology, Inflamation and Immune regulation

Awards: 

Recognition and Award 

• Recipient of Sudev Bhusan Ghosh Young Scientist Award by Zoological society, Kolkata, India, in 2002.

• Guest Editorial member (2013-2014) : Journal of Immunology Research, Hindawi Publishing Corporation;

• “Rapid Grant for Young Investigators” by DBT, Ministry of Science and Technology, India, 2010;

• Received “letter of appreciation” from Director, NISER for excellence in teaching in Advanced Immunology course at School of Biological Sciences, NISER

Life membership:

Society of Biological Chemist (SBC), India, Indian Society of Cell Biology, Indian Immunology Society, Indian Science Congress Association (ISCA), Indian Virological Society (IVS)

Publications: 

Selected publications:

• Sanjai Kumar P, Nayak TK, Mahish C, Sahoo SS, Radhakrishnan A, De S, Datey A, Sahu RP, Goswami C, Chattopadhyay S, Chattopadhyay S*.  Inhibition of transient receptor potential vanilloid 1 (TRPV1) channel regulates chikungunya virus infection in macrophages. Arch Virol. 2021 Jan;166(1):139-155. (* corresponding author) 
• Sahoo SS, Majhi RK, Tiwari A, Acharya T, Kumar PS, Saha S, Kumar A, Goswami C, Chattopadhyay S*. Transient receptor potential ankyrin1 channel is endogenously expressed in T cells and is involved in immune functions.  Biosci Rep. 2019 Sep 20;39(9). pii: BSR20191437. doi: 10.1042/BSR20191437. Print 2019 Sep 30 (* corresponding author)
• Nayak TK, Mamidi P, Sahoo SS, Kumar PS, Mahish C, Chatterjee S, Subudhi BB, Chattopadhyay S and Chattopadhyay S * . P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages.Front. Immunol., 12 April 2019  https ://doi.org/10.3389/fimmu.2019.0078610:786. (* corresponding author)
• Sahoo SS, Pratheek BM, Meena VS, Nayak TK, Kumar SP, Bandyopadhyay S, Maiti PK, Chattopadhyay S*. VIPER regulates naive T cell activation and effector responses: Implication in TLR4 associated acute stage T cell responses. Scientific Reports 2018, 8: 7118(*corresponding author)
• Nayak TK, Mamidi  P, Kumar A, Singh LPK, Sahoo SS, Chattopadhyay S, Chattopadhyay S*. Regulation of Viral Replication, Apoptosis and Pro-Inflammatory Responses by 17-AAG during Chikungunya Virus Infection in Macrophages.Viruses 2017, 9, 3; doi:10.3390/v9010003(* one of the corresponding authors)
• Majhi R, Sahoo S, Yadav J, Pratheek BM, Chattopadhyay S*, Goswami C. Functional Expression of Transient Receptor Potential Vanilloid Channels (TRPV) in T cells And Their Implications in Immune Regulation. FEBS J. 2015 Jul;282(14):2661-81. doi: 10.1111/febs.13306. (* one of the corresponding authors)
• Karimi S, Chattopadhyay S*, Nitya G. Chakraborty. Manipulation of Regulatory T Cells and Antigen Specific CTL-based Tumor Immunotherapy.  Immunology. 2015 Feb;144(2):186-96 (* as one of the corresponding authors)
• Pratheek BM, Suryawanshi AR, Chattopadhyay S, Chattopadhyay S*. In silico analysis of MHC-I restricted epitopes of Chikungunya virus proteins: Implication in understanding anti-CHIKV CD8+ T cell response and advancement of epitope based immunotherapy for CHIKV infection. Infection, Genetics and Evolution. 2015, 31:  118–126 (* as one of the corresponding authors)
• Rath S, Das L, Kokate SB, Pratheek BM, Chattopadhyay S, Goswami C, Chattopadhyay R, Crowe SE, Bhattacharyya A. Regulation of Noxa-mediated apoptosis in Helicobacter pylori-infected gastric epithelial cells. FASEB J. 2015  29, 796-806

• Pradhan N, Pratheek BM, Garai A, Kumar A, Meena VS, Basu S, Singh S, Kumari S, Chandrashekar TK, Goswami C, Chattopadhyay S*, Kar S, Maiti PM. Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells. Cell Biol. Int. 2014 Oct;38(10):1118-31 (* as one of the corresponding authors)
• Das I, Basantray I, Mamidi P, Nayak TK, Pratheek BM, Chattopadhyay S, Chattopadhyay S. Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection. PLoS One. 2014 Jun 24;9(6):e100531
• Chattopadhyay S, Kumar A, Mamidi P, Nayak TK, Das I, Chhatai J, Basantray I, Umarani Bramha U, Maiti PK, Singh S, Suryawanshi AR, Chattopadhyay S. Development and characterization of monoclonal antibody against non-structural protein-2 of Chikungunya virus and its application. Journal of Virological Methods 2014, 199: 86– 94.
• Kumari J, Selvan SR, Becart S, Chattopadhyay S*, Dalmo RA. Special Issue: Cell-mediated Immunity and Vaccines. Journal of Immunology Research, 2014;2014:632632(* as one of the Editorial members)
• Pratheek BM, Saha S, Maiti PK, Chattopadhyay S, Chattopadhyay S*. Immune Regulation and Evasion of Mammalian Host Cell Immunity During Viral Infection. Indian Journal of Virology 2013 Jun; 24(1):1-15. (*corresponding author)
• Chattopadhyay S*, Pal S, Pratheek BM, Meena VM, Singh S, Maiti PK. “Toll" Extending Its Gate from Drosophila Development to T Cell Response: Implication in Innate Immunity, Adaptive Immunity and Immunotherapy. Immunotherapy Insights 2011, 2: 1-14. (*  corresponding author)
• Cone RE, Chattopadhyay S, Sharafieh R, Lemire Y, O’ Rourke J, Flavell RA, and Clark RB. T cell sensitivity to TGF- β is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the Anterior Chamber. Int Immunol. 2009, 21:567-74.
• Chattopadhyay S, O’Rourke J and Cone RE. Implication for the CD94/NKG2A-Qa-1 System in the Generation and Function of Ocular-induced Splenic CD8+ Regulatory T cells. Int Immunol. 2008,  20:509-516
• Cone RE, Chattopadhyay S, Sharafieh R, Lemire Y and O’ Rourke J. The suppression of hypersensitivity by ocular–induced CD8+ T cells requires compatibility in the Qa-1 haplotype. Immunol Cell Biol. 2009 87:241-248.
• Chattopadhyay S, Mehrotra  S, Chhabra A, Hegde U, Mukherji B and Chakraborty NG. Effect of CD4+CD25+ and CD4+CD25- T Regulatory Cells on the Generation of Cytolytic T Cell Response to a Self but Human Tumor-Associated Epitope In Vitro.  J. Immunol. 2006, 176: 984- 990.
• Chattopadhyay S, Chakraborty NG, Mukherji B. Regulatory T cells and tumor immunity. Cancer Immunol Immunother. 2005, 54: 1153- 1161.
• Chattopadhyay S and. Chakraborty N. G. Continuous Presence of TH1 Conditions is Necessary for Longer Lasting Tumor-specific CTL Activity in Stimulation Cultures with PBL. Hum Immunol. 2005, 66: 884- 891.

Research: 

Cellular and Immunological investigation towards altered host cell responses

The fundamental consequences of cellular responses associated to altered physiological processes during infection, cancer and/or tumor progression, inflammation and immunogenic responses in various cases of altered host cell functions and phenotypes are the prime interest of our ongoing research.

We have been working in the field of host cell responses and cellular immunology with special interest of ongoing immune-regulatory responses, cellular function and phenotypes associated to Cell mediated immunity (CMI) of T cells and accessory antigen presenting cells. Currently, we have major interest groups within NISER and also with external collaboration, where we are investigating functional expression of Toll like receptor (TLR) and Transient Receptor Potential Vanilloid (TRPV) Channels in cell mediated immunity (CMI), analyzing cellular and immunological response(s) of host cells during experimental Chikungunya virus (CHIKV) infection along with anti-cancer immunity as major projects.

In brief, our research focuses to dissect out the important roles of cellular and immunological aspects to decipher the cellular pathways, strategies associated to altered host cell responses for an ongoing infection, tumor progression, inflammation-immunity and immuno-regulatory processes associated to diseases biology in different contexts of cellular responses. Research with cell lines, primary cells, animal model and also with the human blood samples from normal donors and patients with due consents and National guide lines are the prime components for such experimental studies. Such understanding will be helpful towards designing immuno-therapeutic strategies to control various diseases.

 

Teaching: 

Courses taught in NISER :

Animal Physiology; Cell Biology; Cancer Biology; Immunology, Advanced Immunology; Immune regulation and Infection immunity

Contacts: 

Dr. Subhasis Chattopadhyay
School of Biological Sciences
National Institute of Science Education and Research

PO- Bhimpur-Padanpur, 
Via- Jatni, District: Khurda, 
Pin code- 752050

Contact SBS Office

Phone No: +91- 674-2494136
Fax:  +91-674-2494138

Phone No.: 

+91-674-2494201

Room No.: 

221, Lab no. 04

Mail ID: 

subho@niser.ac.in